Spotlight FCS

Hypertriglyceridemia is the third most common cause of acute pancreatitis¹

Acute pancreatitis resulting from severe hypertriglyceridemia (HTG) has been associated with longer hospitalization times, increased admission to intensive care units, and higher rates of persistent organ failure compared with acute pancreatitis without HTG.¹

Learn more about causes of pancreatitis

Acute pancreatitis and hypertriglyceridaemia may be signs of FCS, a rare genetic disorder^4,5

FCS is a genetic disorder of lipid metabolism resulting in severe hypertriglyceridemia >885 mg/dl (>10 mmol/L), and the risk of recurrent and potentially fatal pancreatitis.^4,5

Key facts of FCS

Given its rarity and wide range of symptoms FCS can be extremely difficult to recognise

Think of FCS when your patient:⁴

has hypertriglyceridemia
has been treated for pancratitis

Use this diagnostic algorithm to identify FCS patients

FCS diagnostic algorithm

Symptoms and complication of FCS

Learn more about the broad spectrum of signs and symptoms that are associated with FCS.

Diagnosis of FCS

FCS diagnosis is based on a three-step approach: High triglyceride evaluation, Identification of candidates for FCS genetic testing and Genetic test of possible affected genes.

The importance of early diagnosis in FCS

If you suspect FCS in your patient, use the FCS diagnistic score
to support your clinical suspect.⁴

Interactive FCS score

References

Nawaz H, et al. Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis. Am J Gastroenterol. 2015;110:1497-503.
NCEPOD: Treat the cause. Avaliable at www.ncepod.org.uk/2016ap.html
Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. Eur J Intern Med. 2014 Oct;25(8):689-94.
Moulin P, et al. Identification and diagnosis of patients with familial chylomicronaemia syndrome (FCS): Expert panel recommendations and proposal of an ”FCS score”. Atherosclerosis. 2018;275:265-72
Gaudet D, et al. Targeting APOC3 in the Familial Chylomicronemia Syndrome. N Engl J Med. 2014;371:2200-6.

Persistent
hypertriglyceridemia?
Recurrent pancreatitis?

Hypertriglyceridemia is the third most common cause of acute pancreatitis¹

Acute pancreatitis and hypertriglyceridaemia may be signs of FCS, a rare genetic disorder^4,5

Given its rarity and wide range of symptoms FCS can be extremely difficult to recognise

Symptoms and complication of FCS

Diagnosis of FCS

The importance of early diagnosis in FCS

References

You are leaving the Spotlight FCS website

Persistent hypertriglyceridemia? Recurrent pancreatitis?

Hypertriglyceridemia is the third most common cause of acute pancreatitis1

Acute pancreatitis and hypertriglyceridaemia may be signs of FCS, a rare genetic disorder4,5

Given its rarity and wide range of symptoms FCS can be extremely difficult to recognise

Symptoms and complication of FCS

Diagnosis of FCS

The importance of early diagnosis in FCS

References

You are leaving the Spotlight FCS website

Persistent
hypertriglyceridemia?
Recurrent pancreatitis?

Hypertriglyceridemia is the third most common cause of acute pancreatitis¹

Acute pancreatitis and hypertriglyceridaemia may be signs of FCS, a rare genetic disorder^4,5